HRID553732

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C(=O)N1C(=O)O[C@@H](c2ccccc2)[C@H]1C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1

HCID58539564

未命名化合物

结构：Cc1noc(-c2ccc(Br)cc2)c1NC(=O)O[C@H](C)c1ccccc1Cl

HCID66660466

(1R)-1-(2-Chlorophenyl)ethyl N-[5-(4-bromophenyl)-3-methyl-4-isoxazolyl]carbamate

C19H16BrClN2O3

PRODUCTS

生成物

结构：Cc1noc(-c2ccc(-c3ccc(C(C)C(=O)N4C(=O)O[C@@H](c5ccccc5)[C@H]4C)cc3)cc2)c1NC(=O)O[C@H](C)c1ccccc1Cl

HCID67351133

未命名化合物

PROCEDURE

实验过程

Diastereomer B—Prepared as described in Example 36, Step 6 using (4R,5S)-4-methyl-5-phenyl-3-{2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propionyl}-oxazolidin-2-one (Diastereomer B) and [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-carbamic acid (R)-1-(2-chloro-phenyl)-ethyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-abe887cff36748cba6dca7f296612fd9
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08048902B2
来源说明: uspto-grants-2011_11

反应 SMILES

[CH3:1][C@@H:2]1[C@H:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[O:5][C:4](=[O:13])[N:3]1[C:14](=[O:32])[CH:15]([C:17]1[CH:22]=[CH:21][C:20](B2OC(C)(C)C(C)(C)O2)=[CH:19][CH:18]=1)[CH3:16].[Cl:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[C@H:40]([O:42][C:43](=[O:58])[NH:44][C:45]1[C:46]([CH3:57])=[N:47][O:48][C:49]=1[C:50]1[CH:55]=[CH:54][C:53](Br)=[CH:52][CH:51]=1)[CH3:41]>>[Cl:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[C@H:40]([O:42][C:43](=[O:58])[NH:44][C:45]1[C:46]([CH3:57])=[N:47][O:48][C:49]=1[C:50]1[CH:55]=[CH:54][C:53]([C:20]2[CH:19]=[CH:18][C:17]([CH:15]([CH3:16])[C:14]([N:3]3[C@H:2]([CH3:1])[C@H:6]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)[O:5][C:4]3=[O:13])=[O:32])=[CH:22][CH:21]=2)=[CH:52][CH:51]=1)[CH3:41]