Ethanone, 1-(2-chlorophenyl)- → 1-Phenylethanol, (S)-

HRID 553745Notes

Reaction equation

HRID 553745 reaction equation
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].B1(C)OC(C2C=CC=CC=2)(C2C=CC=CC=2)[C@@H]2N1CCC2>>[C:3]1([C@@H:8]([OH:10])[CH3:9])[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1

Participants

3

Reactant 2

HCID 72864Ethanone, 1-(2-chlorophenyl)-HCID 9838490(R)-2-Methyl-CBS-oxazaborolidine

Product 1

HCID 4431351-Phenylethanol, (S)-

Procedure

2′-Chloroacetophenone and (R)-(+)-2-methyl-CBS-oxazaborolidine were reacted as described in Example 35, Step 1 to provide (S)-1-phenyl-ethanol.

Sources & evidence

ORD record
ord-a3f3a7c926df480b98b2a34632772d54
Source dataset
uspto-grants-2011_11
Patent number
US08048902B2

Reaction notes

Loading…