反应详情

2-Fluoro-5-iodo-3-nitro-benzoic acid (2.0 g, 6.43 mmol) and SOCl2 (918 mg, 7.72 mmol) were added to 20 mL MeOH, and the mixture was refluxed for two hours and then cooled to room temperature. Solvent was evaporated under reduced pressure and the residue was dissolved in EtOAa. The EtOAc solution was washed with brine, dried over NaSO4, filtered and concentrated under reduced pressure to give 2.0 g (96%) of 2-fluoro-5-iodo-3-nitro-benzoic acid methyl ester.

1. temperaturethe mixture was refluxed for two hours
2. customSolvent was evaporated under reduced pressure
3. dissolutionthe residue was dissolved in EtOAa
4. washThe EtOAc solution was washed with brine
5. dry with materialdried over NaSO4
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure