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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 553808Generated: October 26, 2026

2-(Aminomethyl)-5-methylpyrazine → 2-fluoro-5-(5-isopropyl-tetrazol-1-yl)-N-(5-methyl-pyrazin-2-ylmethyl)-3-(5-methyl-pyridin-2-yl)-benzamide

https://huagongshe.com/reaction/553808

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Aminomethyl)-5-methylpyrazineHCID 2756496—
Reactant2-Fluoro-5-(5-isopropyl-tetrazol-1-yl)-3-(5-methyl-pyridin-2-yl)-benzoic acidHCID 57749793—
Product2-fluoro-5-(5-isopropyl-tetrazol-1-yl)-N-(5-methyl-pyrazin-2-ylmethyl)-3-(5-methyl-pyridin-2-yl)-benzamideHCID 57749807—

Reaction Steps

2-Fluoro-5-(5-isopropyl-tetrazol-1-yl)-3-(5-methyl-pyridin-2-yl)-benzoic acid was reacted with C-(5-methyl-pyrazin-2-yl)-methylamine using the procedure of step 4 of Example 7 to provide 2-fluoro-5-(5-isopropyl-tetrazol-1-yl)-N-(5-methyl-pyrazin-2-ylmethyl)-3-(5-methyl-pyridin-2-yl)-benzamide, MS (M+H)=447.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08048905B2
Source datasetuspto-grants-2011_11
ORD IDord-d962ff0b3e9f49e9b7b447132313e761
Source noteuspto-grants-2011_11