HCID 67459598, compound → HCID 67463033, compound

HRID 553812Notes

Reaction equation

[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:40])[C@@H:13]([NH:19][C:20]([C:22]2[CH:27]=[C:26]([O:28][CH:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)[N:25]=[C:24]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[N:23]=2)=[O:21])[CH2:14]CC(O)=O)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH2:41]([O:43]C(N1CCN(C(=O)[C@@H](NC(C2C=C(OC3CCCC3)N=C(C3C=CC=CC=3)N=2)=O)CCCC(O)=O)CC1)=O)C>>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][N:9]([C:12](=[O:40])[C@@H:13]([NH:19][C:20]([C:22]2[CH:27]=[C:26]([O:28][CH:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)[N:25]=[C:24]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[N:23]=2)=[O:21])[CH2:14][CH2:41][OH:43])[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 67459598HCID 67459598, compound

HCID 67462216HCID 67462216, compound

Product 1

HCID 67463033HCID 67463033, compound

Procedure

The compounds of Examples 12 and 13 were prepared using a method analogous to that of Example 11, starting from 4-{(S)-4-carboxy-2-[(6-cyclopentyloxy-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester and 4-{(S)-5-carboxy-2-[(6-cyclopentyloxy-2-phenyl-pyrimidine-4-carbonyl)-amino]-pentanoyl}-piperazine-1-carboxylic acid ethyl ester respectively.

Sources & evidence

ORD record: ord-7f86b41fde384b80ade7c5e3084fa936
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08048881B2

Reaction notes

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