HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → HCID 67459852, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzyl piperazine-1-carboxylate | HCID 643495 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67459852 | HCID 67459852 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
Piperazine-1-carboxylic acid benzyl ester (500 mg) was dissolved in DCM (5 ml) and the mixture was cooled down to 0° C. Benzoyl chloride (290 μl) and NEt3 (379 μl) were added. The mixture was stirred for 48 h, diluted with DCM, washed with water, dried (Na2SO4) and evaporated off. After HV, 650 mg of the desired compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048881B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-ecc58d5bb38141edb7b7bbe6c88b777f |
| Source note | uspto-grants-2011_11 |