HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylphenyl boronic acid → 4-{(S)-4-tert-butoxycarbonyl-2-[(2-phenyl-6-o-tolyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylphenyl boronic acid | HCID 2733267 | — |
| Reactant | 4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester | HCID 86622404 | — |
| Product | 4-{(S)-4-tert-butoxycarbonyl-2-[(2-phenyl-6-o-tolyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester | HCID 67458447 | — |
Reaction Steps
This compound was prepared using a method analogous to that of Example 86, step 86.1, 4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester replacing 2-chloro-6-methyl-pyrimidine-4-carboxylic acid methyl ester and 2-tolylboronic acid replacing phenylboronic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048881B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-50fcc07c69fc450697a2685237fee42b |
| Source note | uspto-grants-2011_11 |