2,6-Lutidine → 3-(Tert-butyl-dimethyl-silanyloxy)-butane-2-thiol

Participants

Reaction Conditions

Reaction Steps

2,6-lutidine (163 μl) was added to a solution of 3-mercapto-2-butanol (68 mg) in DCM (5 ml) and the mixture was cooled down to −20° C. Tert-butyldimethylsilyl trifluoromethanesulfonate (163 μl) was slowly added and it was stirred 1 h at −20° C. Another 163 μl of the silyl reagent was added and the mixture was allowed to warm to RT and stirred one might at RT. The mixture was evaporated off and used without purification and characterization.

Provenance & Evidence