Sodium borohydride → HCID 67461439, compound

HRID 553870Notes

Reaction equation

HRID 553870 reaction equation
[BH4-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:18][C:17](=[O:19])[CH2:16][CH:15]3[N:11]2[C:12](=[O:20])[CH2:13][CH2:14]3)=[CH:6][CH:5]=1>C(O)C>[F:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:18][CH:17]([OH:19])[CH2:16][CH:15]3[N:11]2[C:12](=[O:20])[CH2:13][CH2:14]3)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 67463862HCID 67463862, compound

Product 1

HCID 67461439HCID 67461439, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium borohydride (230 mg) was added to a solution of 5-(4-fluorophenyl)hexahydroindolizine-3,7-dione obtained above (500 mg) in ethanol (75 mL) at room temperature, and the reaction solution was stirred for one hour. The reaction solution was added to ice water, followed by extraction with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain 500 mg of the title compound. The property values of the compound are as follows.

Workup

  1. extractionfollowed by extraction with ethyl acetate
  2. washThe extract was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-c28416b6e8d14e0b9768dc1a2a59b833
Source dataset
uspto-grants-2011_11
Patent number
US08048878B2

Reaction notes

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