HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6R*,9aS*)-6-(4-methoxyphenyl)-3,6,7,8,9,9a-hexahydroquinolizin-4-one → (6R*,9aS*)-6-(4-methoxyphenyl)octahydroquinolizin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6R*,9aS*)-6-(4-methoxyphenyl)-3,6,7,8,9,9a-hexahydroquinolizin-4-one | HCID 69072392 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (6R*,9aS*)-6-(4-methoxyphenyl)octahydroquinolizin-4-one | HCID 69070867 | 81.5% |
Reaction Steps
Platinum oxide (2 mg) was added to a solution of (6R*,9aS*)-6-(4-methoxyphenyl)-3,6,7,8,9,9a-hexahydroquinolizin-4-one (28 mg) in methanol (5 mL), and the reaction solution was stirred in a hydrogen stream at room temperature for 13 hours. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain 23 mg of the title compound. The property values of the compound are as follows.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048878B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-962f1dadef664bf0a55ec32702bb57ad |
| Source note | uspto-grants-2011_11 |