Acetic Anhydride → HCID 57779756, compound

HRID 554010Notes

Reaction equation

HRID 554010 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][O:9][C:10]1[CH:11]=[C:12](/[CH:22]=[C:23]2\[CH2:24][CH2:25][C@H:26]3[CH2:31][NH:30][CH2:29][C@@H:28]([C:32]4[CH:37]=[C:36]([F:38])[C:35]([F:39])=[C:34]([F:40])[CH:33]=4)[N:27]3[C:41]\2=[O:42])[CH:13]=[CH:14][C:15]=1[N:16]1[CH:20]=[C:19]([CH3:21])[N:18]=[CH:17]1>N1C=CC=CC=1>[C:1]([N:30]1[CH2:29][C@@H:28]([C:32]2[CH:37]=[C:36]([F:38])[C:35]([F:39])=[C:34]([F:40])[CH:33]=2)[N:27]2[C:41](=[O:42])/[C:23](=[CH:22]/[C:12]3[CH:13]=[CH:14][C:15]([N:16]4[CH:20]=[C:19]([CH3:21])[N:18]=[CH:17]4)=[C:10]([O:9][CH3:8])[CH:11]=3)/[CH2:24][CH2:25][C@H:26]2[CH2:31]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 57779746HCID 57779746, compound

Product 1

HCID 57779756HCID 57779756, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Acetic anhydride (0.5 mL) was added to a solution of (4R*,9aS*)-7-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}-4-(3,4,5-trifluorophenyl)octahydropyrido[1,2-a]pyrazin-6-one (20 mg) in pyridine (1 mL), and the reaction solution was stirred at room temperature for 12 hours. The reaction solution was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (carrier: Chromatorex NH; elution solvent: ethyl acetate->ethyl acetate:methanol 4:1) to obtain 10.2 mg of the title compound. The property values of the compound are as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (carrier: Chromatorex NH; elution solvent: ethyl acetate->ethyl acetate:methanol 4:1)

Sources & evidence

ORD record
ord-163df2b613af4501b28328430e521bca
Source dataset
uspto-grants-2011_11
Patent number
US08048878B2

Reaction notes

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