Dimethylcarbamoyl Chloride → HCID 44136797, compound

Participants

Reaction Conditions

Reaction Steps

IPEA (0.02 mL) and dimethylcarbamyl chloride (0.006 mL) were sequentially added to a solution of (4R*,9aS*)-7-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}-4-(3,4,5-trifluorophenyl)octahydropyrido[1,2-a]pyrazin-6-one (20 mg) in methylene chloride (3 mL), and the reaction solution was stirred at 0° C. for one hour and at room temperature for five hours. Ethyl acetate and saturated sodium bicarbonate water were added to the reaction solution, and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (carrier: Chromatorex NH; elution solvent: heptane:ethyl acetate 1:1->ethyl acetate->ethyl acetate:methanol 4:1) to obtain 17 mg of the title compound. The property values of the compound are as follows.

Provenance & Evidence