HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-fluorobenzylamine → N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-fluorobenzylamine | HCID 139909 | — |
| Reactant | (4-Fluoro-2-(trifluoromethyl)phenyl)methanamine | HCID 2734878 | — |
| Reactant | L-Proline, 1-ethyl-5-oxo- | HCID 18605196 | — |
| Reactant | (2S)-1-methyl-5-oxopyrrolidine-2-carboxylic acid | HCID 18649403 | — |
| Reactant | N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-5-oxoprolinamide | HCID 49864911 | — |
| Product | N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide | HCID 67458706 | — |
Reaction Steps
N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide was prepared in a manner analogous to that described above for the synthesis of N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-5-oxoprolinamide (Example 70) but 1-methyl-5-oxoproline (prepared as describe below) was substituted for 1-ethyl-5-oxoproline and {[4-fluoro-2-(trifluoromethyl)phenyl]methyl}amine was substituted for 2-chloro-4-fluorobenzylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048907B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-c6c8234805c647959e5883507a9420bf |
| Source note | uspto-grants-2011_11 |