2-Chloro-4-fluorobenzylamine → N-[(2-chloro-4-fluorophenyl)methyl]-5-oxo-1-(phenylmethyl)prolinamide

HRID 554117Notes

Reaction equation

HRID 554117 reaction equation
[Cl:1][C:2]1[C:7](C(F)(F)F)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:12][NH:13][C:14](=[O:28])[C@@H:15]1[CH2:19][CH2:18][C:17](=[O:20])[N:16]1[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.ClC1C=C([F:36])C=CC=1CN>>[Cl:1][C:2]1[CH:7]=[C:6]([F:36])[CH:5]=[CH:4][C:3]=1[CH2:12][NH:13][C:14](=[O:28])[C@@H:15]1[CH2:19][CH2:18][C:17](=[O:20])[N:16]1[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 1399092-Chloro-4-fluorobenzylamineHCID 67461192N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-5-oxo-1-(phenylmethyl)prolinamide

Product 1

HCID 49864914N-[(2-chloro-4-fluorophenyl)methyl]-5-oxo-1-(phenylmethyl)prolinamide

Procedure

N-[(2-chloro-4-fluorophenyl)methyl]-5-oxo-1-(phenylmethyl)prolinamide was prepared in an analogous manner to that described for the synthesis of N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-5-oxo-1-(phenylmethyl)prolinamide (Example 92) above but using [(2-chloro-4-fluorophenyl)methyl]amine in the place of {[2-chloro-3-(trifluoromethyl)phenyl]methyl}amine.

Sources & evidence

ORD record
ord-bd8c5373595445c6a57afcd403af3ad5
Source dataset
uspto-grants-2011_11
Patent number
US08048907B2

Reaction notes

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