HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-Benzyl-5-carboxy-2-pyrrolidinone → N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-5-oxo-1-(phenylmethyl)-D-prolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-Benzyl-5-carboxy-2-pyrrolidinone | HCID 10900113 | — |
| Reactant | N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-(2,2-dimethylpropyl)-5-oxoprolinamide | HCID 67460075 | — |
| Product | N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-5-oxo-1-(phenylmethyl)-D-prolinamide | HCID 67463195 | — |
Reaction Steps
N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-5-oxo-1-(phenylmethyl)-D-prolinamide was prepared in an analogous manner to that described for the synthesis of N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-(2,2-dimethylpropyl)-5-oxoprolinamide (example 100) above but using 5-oxo-1-(phenylmethyl)proline in the place of 1-(2,2-dimethylpropyl)-5-oxoproline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048907B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0f616af982214f019ed168149e8314c5 |
| Source note | uspto-grants-2011_11 |