2-Fluoro-3-trifluoromethylbenzylamine → 1-ethyl-N-{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}-5-oxoprolinamide

HRID 554126Notes

Reaction equation

HRID 554126 reaction equation
ClC1C=C(F)C=CC=1CN[C:11](=[O:20])[C@H:12]1[CH2:16][CH2:15][C:14](=[O:17])[N:13]1[CH2:18][CH3:19].[F:21][C:22]1[C:29]([C:30]([F:33])([F:32])[F:31])=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24][NH2:25]>>[CH2:18]([N:13]1[C:14](=[O:17])[CH2:15][CH2:16][C@H:12]1[C:11]([NH:25][CH2:24][C:23]1[CH:26]=[CH:27][CH:28]=[C:29]([C:30]([F:31])([F:32])[F:33])[C:22]=1[F:21])=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 27375652-Fluoro-3-trifluoromethylbenzylamineHCID 49865054N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-5-oxo-D-prolinamide

Product 1

HCID 674607861-ethyl-N-{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}-5-oxoprolinamide

Procedure

1-ethyl-N-{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}-5-oxoprolinamide was prepared in a manner analogous to that described above (see example 70) for N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-5-oxo-D-prolinamide but using 2-fluoro-3-trifluoromethylbenzylamine in the place of 2-chloro-4-fluorobenzylamine.

Sources & evidence

ORD record
ord-c8dde78f602f45af9f71eeec03ec00cc
Source dataset
uspto-grants-2011_11
Patent number
US08048907B2

Reaction notes

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