HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-(trifluoromethyl)benzylamine → N-{[2-Chloro-3-(trifluoromethyl)phenyl]methyl}-1-ethyl-4,4-dimethyl-5-oxoprolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-(trifluoromethyl)benzylamine | HCID 5224207 | — |
| Reactant | N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-4,4-dimethyl-5-oxoprolinamide | HCID 67461683 | — |
| Product | N-{[2-Chloro-3-(trifluoromethyl)phenyl]methyl}-1-ethyl-4,4-dimethyl-5-oxoprolinamide | HCID 67460789 | — |
Reaction Steps
N-{[2-Chloro-3-(trifluoromethyl)phenyl]methyl}-1-ethyl-4,4-dimethyl-5-oxoprolinamide was prepared in a manner analogous to that described above for the synthesis of N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-4,4-dimethyl-5-oxoprolinamide (E130) but using {[2-chloro-3-(trifluoromethyl)phenyl]methyl}amine in the place of [(2-chloro-4-fluorophenyl)methyl]amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048907B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-03fb196d8c4d444c8c328bb1e3ce205e |
| Source note | uspto-grants-2011_11 |