2-Chloro-3-(trifluoromethyl)benzylamine → HCID 67460148, compound

HRID 554158Notes

Reaction equation

HRID 554158 reaction equation
ClC1C=C(F)C=CC=1CN[C:11](=[O:27])[C@@H:12]1[CH2:16][CH:15]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:14](=[O:24])[N:13]1[CH2:25][CH3:26].[Cl:28][C:29]1[C:34]([C:35]([F:38])([F:37])[F:36])=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:39][NH2:40].C(N1C(=O)C(CC2C=CC=CC=2)C[C@H]1C(O)=O)C>>[Cl:28][C:29]1[C:34]([C:35]([F:37])([F:38])[F:36])=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:39][NH:40][C:11](=[O:27])[C@@H:12]1[CH2:16][CH:15]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:14](=[O:24])[N:13]1[CH2:25][CH3:26]

Participants

4

Reactant 3

HCID 52242072-Chloro-3-(trifluoromethyl)benzylamineHCID 67459915HCID 67459915, compoundHCID 67461554HCID 67461554, compound

Product 1

HCID 67460148HCID 67460148, compound

Procedure

N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-ethyl-5-oxo-4-(phenylmethyl)prolinamide was prepared in a manner analogous to that described above for the synthesis of N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-5-oxo-4-(phenylmethyl)-prolinamide (E37), but using {[2-chloro-3-(trifluoromethyl)phenyl]methyl}amine in the place of [(2-chloro-4-fluorophenyl)methyl]amine. Method B, as described in Example 37, was used to prepare the 1-ethyl-5-oxo-4-(phenylmethyl)-proline.

Sources & evidence

ORD record
ord-a02de4a6f5fa4508a3c326046c2b4141
Source dataset
uspto-grants-2011_11
Patent number
US08048907B2

Reaction notes

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