(2S)-1-methyl-5-oxopyrrolidine-2-carboxylic acid → HCID 67458874, compound

HRID 554159Notes

Reaction equation

HRID 554159 reaction equation
[C:1]([C:3]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:13][NH:14][C:15](=[O:24])[C@@H:16]1[CH2:20][CH2:19][C:18](=[O:21])[N:17]1[CH2:22]C)#[N:2].CN1C(=O)CC[C@H]1C(O)=O>>[C:1]([C:3]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:13][NH:14][C:15](=[O:24])[C@@H:16]1[CH2:20][CH2:19][C:18](=[O:21])[N:17]1[CH3:22])#[N:2]

Participants

3

Reactant 2

HCID 18649403(2S)-1-methyl-5-oxopyrrolidine-2-carboxylic acidHCID 67461070HCID 67461070, compound

Product 1

HCID 67458874HCID 67458874, compound

Procedure

N-{[2-Cyano-3-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide was prepared in a manner analogous to that described above for the synthesis of N-{[2-cyano-3-(trifluoromethyl)phenyl]methyl}-1-ethyl-5-oxoprolinamide (E105) but using 1-methyl-5-oxo-proline in place of 1-ethyl-5-oxo-proline.

Sources & evidence

ORD record
ord-41baffa91d944523b8784af6702a8506
Source dataset
uspto-grants-2011_11
Patent number
US08048907B2

Reaction notes

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