Ethyl 2-acetyl-4-oxo-4-phenylbutanoate → Ethyl 2-methyl-5-phenyl-1H-pyrrole-3-carboxylate

Participants

Reaction Conditions

Reaction Steps

Ethyl 2-acetyl-4-oxo-4-phenylbutanoate (3.0 g) and ammonium acetate (1.39 g) were added to acetic acid (20 mL), and the mixture was stirred at 80° C. for 18 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=9:1→1:1) to give the title compound as a brown solid (yield 1.25 g, 45%).

Provenance & Evidence