o-Toluenesulfonyl chloride → HCID 86232940, compound

HRID 554172Notes

Reaction equation

HRID 554172 reaction equation
CC1C=CC=CC=1S(Cl)(=O)=O.[CH3:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[S:19]([N:22]1[C:26]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:25][C:24]([C:33](OCC)=[O:34])=[CH:23]1)(=[O:21])=[O:20]>>[CH3:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[S:19]([N:22]1[C:26]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:25][C:24]([CH:33]=[O:34])=[CH:23]1)(=[O:21])=[O:20]

Participants

3

Reactant 2

HCID 8623o-Toluenesulfonyl chlorideHCID 66924928HCID 66924928, compound

Product 1

HCID 86232940HCID 86232940, compound

Procedure

Using 2-methylbenzenesulfonyl chloride instead of tosyl chloride, a procedure as in Reference Example 4 was performed to synthesize ethyl 1-[(2-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carboxylate, and procedures as in Reference Examples 5 and 6 were sequentially performed to give the title compound as a colorless oil.

Sources & evidence

ORD record
ord-a991920336484e4ba3b32812e238ac50
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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