4-(Trifluoromethyl)benzenesulfonyl chloride → HCID 86620737, compound

HRID 554173Notes

Reaction equation

HRID 554173 reaction equation
FC(F)(F)C1C=CC(S(Cl)(=O)=O)=CC=1.[C:15]1([C:21]2[N:25]([S:26]([C:29]3[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][CH:30]=3)(=[O:28])=[O:27])[CH:24]=[C:23]([C:39](OCC)=[O:40])[CH:22]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:15]1([C:21]2[N:25]([S:26]([C:29]3[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:36])[F:37])=[CH:31][CH:30]=3)(=[O:27])=[O:28])[CH:24]=[C:23]([CH:39]=[O:40])[CH:22]=2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 66924722HCID 66924722, compound

Product 1

HCID 86620737HCID 86620737, compound

Procedure

Using 4-trifluoromethylbenzenesulfonyl chloride instead of tosyl chloride, a procedure as in Reference Example 4 was performed to synthesize ethyl 5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrole-3-carboxylate, and procedures as in Reference Examples 5 and 6 were sequentially performed to give the title compound as a colorless solid.

Sources & evidence

ORD record
ord-cf7b27563abc47e9a4f083025d2f792c
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

Loading…