HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tosylmethyl isocyanide → Methyl 4-methyl-1H-pyrrole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tosylmethyl isocyanide | HCID 161915 | — |
| Reactant | Methyl Crotonate | HCID 638132 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Product | Methyl 4-methyl-1H-pyrrole-3-carboxylate | HCID 15274278 | 25% |
Reaction Steps
Using p-toluenesulfonylmethyl isocyanide (94.6 g), methyl crotonate (48.5 g) and potassium tert-butoxide (76.7 g), a procedure as in Reference Example 39 was performed to give the title compound as a pale-yellow solid (yield 16.8 g, 25%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-dc2a31e15c8942f6bb59000738d4cac4 |
| Source note | uspto-grants-2011_11 |