HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tosylmethyl isocyanide → Methyl 4-ethyl-1H-pyrrole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tosylmethyl isocyanide | HCID 161915 | — |
| Reactant | Methyl pent-2-enoate | HCID 519179 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Product | Methyl 4-ethyl-1H-pyrrole-3-carboxylate | HCID 53419689 | 64% |
Reaction Steps
Using p-toluenesulfonylmethyl isocyanide (10.1 g), methyl 2-pentenoate (6.01 g) and potassium tert-butoxide (7.01 g), a procedure as in Reference Example 39 was performed to give the title compound as pale-yellow crystals (yield 5.05 g, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-172882b642284e0bba6bb7c1b956104f |
| Source note | uspto-grants-2011_11 |