HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tosylmethyl isocyanide → Methyl 4-propyl-1H-pyrrole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tosylmethyl isocyanide | HCID 161915 | — |
| Reactant | Methyl 2-hexenoate, (2E)- | HCID 5364409 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Product | Methyl 4-propyl-1H-pyrrole-3-carboxylate | HCID 53632572 | 38% |
Reaction Steps
Using p-toluenesulfonylmethyl isocyanide (8.6 g), methyl (2E)-hex-2-enoate (5.67 g) and potassium tert-butoxide (5.9 g), a procedure as in Reference Example 39 was performed to give the title compound as colorless crystals (yield 2.8 g, 38%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-f80bb939a73a45eb906b7e3a74dd1bfb |
| Source note | uspto-grants-2011_11 |