HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propenoic acid, 3-phenyl-, methyl ester → Methyl 4-phenyl-1H-pyrrole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propenoic acid, 3-phenyl-, methyl ester | HCID 7644 | — |
| Reactant | Tosylmethyl isocyanide | HCID 161915 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Product | Methyl 4-phenyl-1H-pyrrole-3-carboxylate | HCID 5142464 | 52.2% |
Reaction Steps
Using p-toluenesulfonylmethyl isocyanide (10.1 g), methyl cinnamate (8.33 g) and potassium tert-butoxide (6.97 g), a procedure as in Reference Example 39 was performed to give the title compound as pale-yellow crystals (yield 5.40 g, 52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-438611cc20004520a93edf229b991950 |
| Source note | uspto-grants-2011_11 |