HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → Methyl 5-phenyl-4-propyl-1H-pyrrole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | Methyl 5-bromo-1-(phenylsulfonyl)-4-propyl-1H-pyrrole-3-carboxylate | HCID 66924749 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | Methyl 5-phenyl-4-propyl-1H-pyrrole-3-carboxylate | HCID 66924692 | 80.2% |
Reaction Steps
Using methyl 5-bromo-1-(phenylsulfonyl)-4-propyl-1H-pyrrole-3-carboxylate (3.96 g), phenylboronic acid (2.5 g), tetrakis(triphenylphosphine)palladium (1.79 g) and sodium carbonate (3.28 g), a procedure as in Reference Example 56 was performed to give the title compound as a pale-yellow oil (yield 2.0 g, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-dc0bb1b1aac84e6986ac1fcc6dabc8e9 |
| Source note | uspto-grants-2011_11 |