反应详情

To a solution of 2-fluoro-4-nitrobenzonitrile (2.51 g) in methanol (125 mL) was added 10% palladium carbon (50% containing water, 237 mg), and the mixture was stirred under a hydrogen atmosphere for 3 hr. The reaction mixture was filtrated, and the filtrate was concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (eluent: hexane-ethyl acetate=1:1) to give the title compound as a pale-yellow solid (yield 1.43 g, 70%).

1. filtrationThe reaction mixture was filtrated
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue was purified by basic silica gel column chromatography (eluent: hexane-ethyl acetate=1:1)