HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → Ethyl 2-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Ethyl 2-methyl-3-pyrrolecarboxylate | HCID 136747 | — |
| Product | Ethyl 2-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate | HCID 53237932 | — |
Reaction Steps
By a similar operation as in Reference Example 41 and using ethyl 2-methyl-1H-pyrrole-3-carboxylate (8.81 g), sodium hydride (60% in oil, 2.58 g) and benzenesulfonyl chloride (7.8 mL), the title compound was obtained as white crystals (yield 14.3 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-648cc3e04bf846dcaf0da43c81655b07 |
| Source note | uspto-grants-2011_11 |