HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Methyl 5-bromo-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 15-Crown-5 | HCID 36336 | — |
| Reactant | 3-(Methylsulfonyl)benzenesulfonyl chloride | HCID 220330 | — |
| Reactant | Methyl 5-bromo-1H-pyrrole-3-carboxylate | HCID 23271158 | — |
| Product | Methyl 5-bromo-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carboxylate | HCID 66924677 | 92% |
Reaction Steps
Using methyl 5-bromo-1H-pyrrole-3-carboxylate (2.89 g), sodium hydride (60% in oil, 850 mg), 15-crown-5 (4.69 g) and 3-methylsulfonylbenzenesulfonyl chloride (4.38 g), a procedure as in Reference Example 146 was performed to give the title compound as white crystals (yield 5.50 g, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-1cd851f7461647e5ba82984777d70cd6 |
| Source note | uspto-grants-2011_11 |