Water → HCID 66924870, compound

Participants

Reaction Conditions

Reaction Steps

Under an argon atmosphere, a suspension of ethyl 5-bromo-4-methyl-1-[(3-methylphenyl)sulfonyl]-1H-pyrrole-3-carboxylate (2.80 g), phenylboronic acid (1.84 g), tetrakis(triphenylphosphine)palladium (0.84 g), sodium carbonate (2.31 g) in 1,2-dimethoxyethane (12 mL)-water (12 mL) was stirred at 70° C. for 12 hr. After cooling, the reaction mixture was filtered through celite, and celite was washed with ethyl acetate. The organic layer was separated from the filtrate, washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=9:1→7:3) to give the title compound as a colorless oil (yield 2.67 g, 96%).

Provenance & Evidence