HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisobutylaluminumhydride → [2-methyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Reactant | Ethyl 2-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate | HCID 53237932 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | [2-methyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methanol | HCID 66924976 | 96% |
Reaction Steps
Using ethyl 2-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate (8.05 g) and a 1.5 mol/L solution (55 mL) of diisobutylaluminum hydride in toluene, a procedure as in Reference Example 5 was performed to give the title compound as white crystals (yield 6.61 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-b60161726a4045c9ae669e0ff4373b82 |
| Source note | uspto-grants-2011_11 |