Diisobutylaluminumhydride → [5-Bromo-4-ethyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methanol

Participants

Role	Name	HCID	Charge
Reactant	Diisobutylaluminumhydride	HCID 21225700	—
Reactant	Methyl 5-bromo-4-ethyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate	HCID 66924922	—
Solvent	Toluene	HCID 1140	—
Product	[5-Bromo-4-ethyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methanol	HCID 66924674	88.1%

Reaction Steps

Using methyl 5-bromo-4-ethyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate (1.35 g) and a 1.5 mol/L solution (7.5 mL) of diisobutylaluminum hydride in toluene, a procedure as in Reference Example 5 was performed to give the title compound as a brown oil (yield 1.10 g, 88%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08048909B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-566c35ff4e9c4279ac57dc950728c970
Source note	uspto-grants-2011_11