Diisobutylaluminumhydride → HCID 66924770, compound

HRID 554286Notes

Reaction equation

HRID 554286 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([N:11]2[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:14][C:13]([C:22](OCC)=[O:23])=[C:12]2[CH3:27])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[H-].C([Al+]CC(C)C)C(C)C>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([N:11]2[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:14][C:13]([CH2:22][OH:23])=[C:12]2[CH3:27])(=[O:9])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 66924617HCID 66924617, compound

Product 1

HCID 66924770HCID 66924770, compoundYield 48.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Using ethyl 1-[(3-chlorophenyl)sulfonyl]-2-methyl-5-phenyl-1H-pyrrole-3-carboxylate (0.80 g) and a 1.5 mol/L solution (4.0 mL) of diisobutylaluminum hydride in toluene, a procedure as in Reference Example 5 was performed to give the title compound as a brown oil (yield 345 mg, 48%).

Sources & evidence

ORD record
ord-3821fe7ddf2244db841350dbf840ceb7
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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