HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisobutylaluminumhydride → [5-Phenyl-1-(phenylsulfonyl)-4-propyl-1H-pyrrol-3-yl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Reactant | Methyl 5-phenyl-1-(phenylsulfonyl)-4-propyl-1H-pyrrole-3-carboxylate | HCID 66924675 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | [5-Phenyl-1-(phenylsulfonyl)-4-propyl-1H-pyrrol-3-yl]methanol | HCID 66925059 | 98.2% |
Reaction Steps
Using methyl 5-phenyl-1-(phenylsulfonyl)-4-propyl-1H-pyrrole-3-carboxylate (3.0 g), and a 1.5 mol/L solution (16.1 mL) of diisobutylaluminum hydride in toluene, a procedure as in Reference Example 5 was performed to give the title compound as a pale-red oil (yield 2.73 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-05d84c0e8fe24ca2bf12cef8485effe8 |
| Source note | uspto-grants-2011_11 |