Hydrochloric Acid → HCID 66924737, compound

Participants

Reaction Conditions

Reaction Steps

A solution (20 mL) of ethyl 2-chloro-4-fluoro-5-phenyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate (250 mg) in tetrahydrofuran was cooled to −70° C., and a 1.5 mol/L solution (6 mL) of diisobutylaluminum hydride in toluene was added dropwise by small portions. The mixture was further stirred at −70° C. for 1 hr, 1 mol/L hydrochloric acid (50 mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=7:3→1:1) to give the title compound as a colorless oil (yield 210 mg, 94%).

Provenance & Evidence