Sulfur trioxide → HCID 86620743, compound

HRID 554300Notes

Reaction equation

HRID 554300 reaction equation
[Br:1][C:2]1[N:6]([S:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:11]=2)(=[O:9])=[O:8])[CH:5]=[C:4]([CH2:20][OH:21])[CH:3]=1.S(=O)(=O)=O>>[Br:1][C:2]1[N:6]([S:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:11]=2)(=[O:8])=[O:9])[CH:5]=[C:4]([CH:20]=[O:21])[CH:3]=1

Participants

3

Reactant 2

HCID 24682Sulfur trioxideHCID 66924732HCID 66924732, compound

Product 1

HCID 86620743HCID 86620743, compoundYield 58%

Procedure

Using {5-bromo-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrol-3-yl}methanol (4.88 g) and sulfur trioxide.pyridine complex (2.19 g), a procedure as in Reference Example 191 was performed to give the title compound as a white solid (yield 2.80 g, 58%).

Sources & evidence

ORD record
ord-c9b256ecf46843c998bfc4db4caeec37
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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