HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → tert-Butyl [(1-{[3-(methylsulfonyl)phenyl]sulfonyl}-5-(3-pyridyl)-1H-pyrrol-3-yl)methyl]methylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Pyridinylboronic acid | HCID 2734378 | — |
| Reactant | tert-butyl [(5-bromo-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate | HCID 66924810 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | tert-Butyl [(1-{[3-(methylsulfonyl)phenyl]sulfonyl}-5-(3-pyridyl)-1H-pyrrol-3-yl)methyl]methylcarbamate | HCID 66925104 | 67% |
Reaction Steps
Using tert-butyl [(5-bromo-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate (459 mg), 3-pyridineboronic acid (222 mg), sodium carbonate (287 mg) and tetrakis(triphenylphosphine)palladium (53.1 mg), a procedure as in Reference Example 267 was performed to give the title compound as a white solid (yield 305 mg, 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-331d416b42354c5480fcf55d4a85d94f |
| Source note | uspto-grants-2011_11 |