HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methanamine, hydrochloride (1:1) → N-Methyl-1-{5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl}methanamine hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methanamine, hydrochloride (1:1) | HCID 11637 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | 5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3-carbaldehyde | HCID 86620774 | — |
| Produkt | N-Methyl-1-{5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-3-yl}methanamine hydrochloride | HCID 66924776 | 69% |
Reaktionsschritte
Using 5-(3-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3-carbaldehyde (0.57 g), methylammonium chloride (1.38 g) and sodium cyanoborohydride (0.32 g), a procedure as in Example 4 was performed to give the title compound as white crystals (yield 0.45 g, 69%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08048909B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-05c8986e4e1942aba52aa224b8be9d61 |
| Quellennotiz | uspto-grants-2011_11 |