HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanamine, hydrochloride (1:1) → 1-[1-[(4-Fluorophenyl)sulfonyl]-5-(4-methoxyphenyl)-1H-pyrrol-3-yl]-N-methylmethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanamine, hydrochloride (1:1) | HCID 11637 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 1-(4-fluorophenylsulfonyl)-5-(4-methoxyphenyl)-1H-pyrrole-3-carbaldehyde | HCID 86620739 | — |
| Product | 1-[1-[(4-Fluorophenyl)sulfonyl]-5-(4-methoxyphenyl)-1H-pyrrol-3-yl]-N-methylmethanamine | HCID 66925033 | 44.6% |
Reaction Steps
Using 1-(4-fluorophenylsulfonyl)-5-(4-methoxyphenyl)-1H-pyrrole-3-carbaldehyde (0.28 g), methylammonium chloride (0.62 g) and sodium cyanoborohydride (0.15 g), a procedure as in Example 6 was performed to give the title compound as a colorless oil (yield 0.13 g, 44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-4426c66c964b4cf8ad2a35248b21956f |
| Source note | uspto-grants-2011_11 |