HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methanamine, hydrochloride (1:1) → 1-{1-[(4-Fluorophenyl)sulfonyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methanamine, hydrochloride (1:1) | HCID 11637 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | 1-[(4-Fluorophenyl)sulfonyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde | HCID 86620740 | — |
| Produkt | 1-{1-[(4-Fluorophenyl)sulfonyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride | HCID 66925302 | 53,1% |
Reaktionsschritte
Using 1-[(4-fluorophenyl)sulfonyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde (0.55 g), methylammonium chloride (1.17 g) and sodium cyanoborohydride (0.27 g), a procedure as in Example 4 was performed to give the title compound as a colorless crystal (yield 0.33 g, 53%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08048909B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-14d2bcb13dea4207a4d02c822d93dd90 |
| Quellennotiz | uspto-grants-2011_11 |