HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-{1-[(4-Isopropoxyphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}-N-methylmethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(Propan-2-yloxy)benzene-1-sulfonyl chloride | HCID 22327297 | — |
| Reactant | Tert-butyl methyl[(5-phenyl-1H-pyrrol-3-YL)methyl]carbamate | HCID 57522146 | — |
| Product | 1-{1-[(4-Isopropoxyphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}-N-methylmethanamine | HCID 66925291 | 50% |
Reaction Steps
Using tert-butyl methyl[(5-phenyl-1H-pyrrol-3-yl)methyl]carbamate (70 mg), sodium hydride (60% in oil, 98 mg) and 4-isopropoxybenzenesulfonyl chloride (201 mg), a procedure as in Example 38 was performed to give the title compound as pale-red crystals (yield 47 mg, 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-fb4e21ab59614f68bf193d2a51f61da5 |
| Source note | uspto-grants-2011_11 |