HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium hydride → 1-{1-[(3-Methoxyphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | 3-Methoxybenzenesulfonyl chloride | HCID 2737504 | — |
| Edukt | Tert-butyl methyl[(5-phenyl-1H-pyrrol-3-YL)methyl]carbamate | HCID 57522146 | — |
| Produkt | 1-{1-[(3-Methoxyphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride | HCID 57522143 | 68% |
Reaktionsschritte
Using tert-butyl methyl[(5-phenyl-1H-pyrrol-3-yl)methyl]carbamate (200 mg), sodium hydride (60% in oil, 140 mg) and 3-methoxybenzenesulfonyl chloride (433 mg), a procedure as in Example 36 was performed to give the title compound as pale-purple crystals (yield 186 mg, 68%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08048909B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-f966d1dcaa354d3d9c3bcb083e1943db |
| Quellennotiz | uspto-grants-2011_11 |