Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 3-({4-[(Methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3-Cyanobenzene-1-sulfonyl chloride | HCID 2801360 | — |
| 반응물 | Tert-butyl methyl[(5-phenyl-1H-pyrrol-3-YL)methyl]carbamate | HCID 57522146 | — |
| 생성물 | 3-({4-[(Methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride | HCID 66925243 | 58% |
반응 단계
Using tert-butyl methyl[(5-phenyl-1H-pyrrol-3-yl)methyl]carbamate (250 mg), sodium hydride (60% in oil, 175 mg) and 3-cyanobenzenesulfonyl chloride (528 mg), a procedure as in Example 36 was performed to give the title compound as pale-purple crystals (yield 195 mg, 58%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08048909B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-b030c6d8e20a49aa80d89d8aa069bccc |
| 출처 메모 | uspto-grants-2011_11 |