Hydrochloric Acid → HCID 66924996, compound

Participants

Reaction Steps

1-[(3-Nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde (750 mg) was dissolved in methanol (50 mL), 40% methylamine methanol solution (1.64 g) was added at room temperature, and the mixture was stirred for 30 min. Sodium borohydride (240 mg) was added at room temperature, and the mixture was stirred for 10 min. 1 mol/L Hydrochloric acid (100 mL) was added, and the mixture was stirred for 5 min. The reaction mixture was alkalized with a saturated aqueous sodium hydrogencarbonate solution and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate. The mixture was concentrated under reduced pressure to give a free base of the title compound as a crude product. A part (50 mg) of the obtained crude free base was dissolved in methanol (10 mL), a 4 mol/L hydrogen chloride-ethyl acetate solution (1 mL) was added, and the mixture was concentrated under reduced pressure. The residue was crystallized from ethyl acetate to give the title compound as colorless crystals (yield 43 mg, 5%).

Provenance & Evidence