Umbelliferone → 7-(3-Aza-spiro[5.5]undec-9-yloxy)-chromen-2-one

HRID 554472Notes

Reaction equation

HRID 554472 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.C(OC([N:20]1[CH2:25][CH2:24][C:23]2([CH2:30][CH2:29][CH:28](O)[CH2:27][CH2:26]2)[CH2:22][CH2:21]1)=O)(C)(C)C>>[CH2:22]1[C:23]2([CH2:30][CH2:29][CH:28]([O:1][C:2]3[CH:11]=[C:10]4[C:5]([CH:6]=[CH:7][C:8](=[O:12])[O:9]4)=[CH:4][CH:3]=3)[CH2:27][CH2:26]2)[CH2:24][CH2:25][NH:20][CH2:21]1

Participants

3

Reactant 2

HCID 5281426UmbelliferoneHCID 66701044tert-Butyl 9-hydroxy-3-azaspiro[5.5]undecane-3-carboxylate

Product 1

HCID 119845967-(3-Aza-spiro[5.5]undec-9-yloxy)-chromen-2-one

Procedure

Was prepared according to method A from 7-hydroxycoumarin and 9-hydroxy-3-aza-spiro[5.5]undecane-3-carboxylic acid tert-butyl ester.

Workup

  1. customWas prepared

Sources & evidence

ORD record
ord-3d714719457940ae801d11e4a26dee50
Source dataset
uspto-grants-2011_11
Patent number
US08049012B2

Reaction notes

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