反应详情

1-[4-(8-Nitroquinolin-4-yloxy)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)urea (12.0 mg, 0.027 mmol) and tin (II) chloride (25.9 mg, 0.11 mmol) were dissolved in ethanol (0.23 mL), and then refluxed with stirring for 30 minutes. When the reaction was completed, the solvent was removed by vacuum distillation, the resultant was extracted with ethyl acetate and saturated sodium bicarbonate. Combined organic layers were dried with anhydrous sodium sulfate, and then filtered. The solvent was removed and then filtered a brown solid product to obtain 8.1 mg of the desired compound (yield 75.0%).

1. temperaturerefluxed
2. customthe solvent was removed by vacuum distillation
3. extractionthe resultant was extracted with ethyl acetate and saturated sodium bicarbonate
4. dry with materialCombined organic layers were dried with anhydrous sodium sulfate
5. filtrationfiltered
6. customThe solvent was removed
7. filtrationfiltered a brown solid product