Hydrochloric Acid → HCID 67458560, compound

Participants

Reaction Conditions

Reaction Steps

A 20% palladium hydroxide catalyst (150 mg) was added to a solution of (2-benzyloxyphenyl)-(4-trifluoromethoxyphenyl)methanol (1.5 g, 4.01 mmol) in methanol (27 mL) and furthermore 36% HCl (0.33 mL) was added thereto. The mixture solution was stirred under a hydrogen atmosphere for 16 hours, and then cooled to 0° C., potassium carbonate (0.54 g) added thereto and the mixture was stirred for 30 minutes, and then the catalyst was removed by filtration. The solvent was distilled under reduced pressure and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:10)] to obtain a white solid title compound (1.05 g, 97%).

Provenance & Evidence