Potassium Carbonate → HCID 67460430, compound

Participants

Reaction Steps

In a nitrogen stream, triethylsilane (1.84 mL, 11.55 mmol) and a boron trifluoride-diethylether complex (1.33 mL, 10.5 mmol) were added to a solution of (2-benzyloxyphenyl)-(4-bromophenyl)methanol (3.88 g, 10.5 mmol) in acetonitrile (19.5 mL) at −40° C. and the mixture was stirred at the same temperature for 0.5 hour. A saturated potassium carbonate aqueous solution was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution and dried (anhydrous magnesium sulfate), and then the solvent was distilled under reduced pressure. The obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:10)] to obtain the title compound (2.86 g, 77%).

Provenance & Evidence