Hydrochloric Acid → HCID 67460460, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[4-(2-benzyloxybenzyl)phenyl]-cyclopentanol (1.14 g, 3.19 mmol) in methanol (21 mL), a 20% palladium hydroxide catalyst (114 mg) was added, and furthermore 36% HCl (0.255 mL) was added thereto. The mixture was stirred under a hydrogen atmosphere overnight, and then cooled to 0° C., potassium carbonate (425 mg) was added thereto and the mixture was stirred for 20 minutes, and then the catalyst was filtered off. The solvent was distilled under reduced pressure and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:20)] to obtain the title compound (744 mg, 92%) as a white solid.

Provenance & Evidence